Therapeutic Angiogenesis: Another Passing Phase?
نویسندگان
چکیده
منابع مشابه
Therapeutic angiogenesis: another passing phase?
Efforts to stimulate tissue vascularization in patients with ischemia resulting from coronary or peripheral arterial disease (therapeutic angiogenesis1,2) have passed through several scientific phases over the last dozen years, based on our increased understanding of the molecular mechanisms underlying vascular homeostasis (Table). In the first phase, a single angiogenic growth factor, or its c...
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Restoring blood flow is the most effective means to limit damage to ischemic tissue. Since the 1960s, surgical placement of bypass grafts for coronary artery disease (CAD) and peripheral vascular disease has effectively and durably restored blood flow to ischemic tissue. Nonsurgical revascularization was introduced clinically starting in the 1970s. Thrombolytic therapy is used to treat acute th...
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Therapeutic angiogenesis constitutes a fundamental survival mechanism that acts to preserve the integrity of tissues subjected to ischemia. Supplemental administration of angiogenic cytokines--as recombinant protein or plasmid DNA--have been shown to augment collateral development when endogenous angiogenesis is suboptimal for organ function, and thus constitute a novel therapeutic option for t...
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Vascular endothelial growth factor (VEGF) is a heparin-binding, endothelial cell-specific mitogen. Previous studies have suggested thatVEGF is a regulator ofnaturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis that the angiogenic potential of VEGF is sufficient to constitute a therapeutic effect. The soluble 165amino acid isoform ofVEGF was a...
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Atherosclerotic disease of the arteries is a major cause of coronary artery disease, peripheral vascular disease and stroke. Some patients are however not candidate for the standard treatment of angioplasty or bypass surgery. Hence there is tremendous enthusiasm for the utilization of angiogenesis as a therapeutic modality for atherosclerotic arterial disease. This augmentation of physiological...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000223485.43020.9e